1NI4
HUMAN PYRUVATE DEHYDROGENASE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Pyruvate dehydrogenase E1 component: Alpha subunit | polymer | 365 | 41277.2 | 2 | UniProt (P08559) Pfam (PF00676) | Homo sapiens (human) | PDHE1-A type I |
| 2 | B, D (B, D) | Pyruvate dehydrogenase E1 component: Beta subunit | polymer | 341 | 37956.5 | 2 | UniProt (P11177) Pfam (PF02779) Pfam (PF02780) | Homo sapiens (human) | PDHE1-B |
| 3 | E, H (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | F, I (A, C) | THIAMINE DIPHOSPHATE | non-polymer | 425.3 | 2 | Chemie (TPP) | |||
| 5 | G, J (B, D) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 6 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 742 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 361 (UniProt: P08559)
B, D: 1 - 329 (UniProt: P11177)
| PDB | External Database | Details |
|---|---|---|
| Met -3 | - | cloning artifact |
| Arg -2 | - | cloning artifact |
| Gly -1 | - | cloning artifact |
| Ser 0 | - | cloning artifact |
| Mse 38 | Met 67 | modified residue |
| Mse 39 | Met 68 | modified residue |
| Mse 45 | Met 74 | modified residue |
| Mse 124 | Met 153 | modified residue |
| Mse 126 | Met 155 | modified residue |
| Mse 181 | Met 210 | modified residue |
| Mse 200 | Met 229 | modified residue |
| Mse 228 | Met 257 | modified residue |
| Mse 253 | Met 282 | modified residue |
| Mse 265 | Met 294 | modified residue |
| Mse 289 | Met 318 | modified residue |
| Mse 295 | Met 324 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Met -11 | - | cloning artifact |
| Arg -10 | - | cloning artifact |
| Gly -9 | - | cloning artifact |
| Ser -8 | - | cloning artifact |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| Gly -1 | - | cloning artifact |
| Ser 0 | - | cloning artifact |
| Leu 1 | - | SEE REMARK 999 |
| Mse 13 | Met 43 | modified residue |
| Mse 60 | Met 90 | modified residue |
| Mse 71 | Met 101 | modified residue |
| Mse 81 | Met 111 | modified residue |
| Mse 87 | Met 117 | modified residue |
| Mse 103 | Met 133 | modified residue |
| Mse 175 | Met 205 | modified residue |
| Mse 238 | Met 268 | modified residue |
| Mse 244 | Met 274 | modified residue |
| Mse 246 | Met 276 | modified residue |
| Mse 254 | Met 284 | modified residue |
| Mse 280 | Met 310 | modified residue |
| Mse 302 | Met 332 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 158467.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 977.4 | |
| All* | Total formula weight | 159444.8 |
