1NHZ

Crystal Structure of the Antagonist Form of Glucocorticoid Receptor

Summary for 1NHZ

• Entry DOI: 10.2210/pdb1nhz/pdb
• Descriptor: GLUCOCORTICOID RECEPTOR, 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, HEXANE-1,6-DIOL, ... (4 entities in total)
• Functional Keywords: protein-ligand complex, anti parallel alpha helix sandwich, hormone receptor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 32939.19

Authors

Kauppi, B.,Jakob, C.,Farnegardh, M.,Yang, J.,Ahola, H.,Alarcon, M.,Calles, K.,Engstrom, O.,Harlan, J.,Muchmore, S.,Ramqvist, A.-K.,Thorell, S.,Ohman, L.,Greer, J.,Gustafsson, J.-A.,Carlstedt-Duke, J.,Carlquist, M. (deposition date: 2002-12-20, release date: 2003-05-06, Last modification date: 2024-02-14)

• Primary citation: Kauppi, B.,Jakob, C.,Farnegardh, M.,Yang, J.,Ahola, H.,Alarcon, M.,Calles, K.,Engstrom, O.,Harlan, J.,Muchmore, S.,Ramqvist, A.-K.,Thorell, S.,Ohman, L.,Greer, J.,Gustafsson, J.-A.,Carlstedt-Duke, J.,Carlquist, M.; The Three-dimensional Structures of Antagonistic and Agonistic Forms of the Glucocorticoid Receptor Ligand-binding Domain: RU-486 INDUCES A TRANSCONFORMATION THAT LEADS TO ACTIVE ANTAGONISM.; J.Biol.Chem., 278:22748-22754, 2003; PubMed: 12686538; DOI: 10.1074/jbc.M212711200

Experimental method

X-RAY DIFFRACTION (2.3 Å)