1NHZ
Crystal Structure of the Antagonist Form of Glucocorticoid Receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GLUCOCORTICOID RECEPTOR | polymer | 280 | 32155.1 | 1 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (human) | GR |
| 2 | B (A) | 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE | non-polymer | 429.6 | 1 | Chemie (486) | |||
| 3 | C, D, E (A) | HEXANE-1,6-DIOL | non-polymer | 118.2 | 3 | Chemie (HEZ) | |||
| 4 | F (A) | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A: 500 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 498 | - | cloning artifact |
| Ser 499 | - | cloning artifact |
| Asp 517 | Asn 517 | engineered mutation |
| Ser 602 | Phe 602 | engineered mutation |
| Asp 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32155.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 784.1 | |
| All* | Total formula weight | 32939.2 |
