1NHZ
Crystal Structure of the Antagonist Form of Glucocorticoid Receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GLUCOCORTICOID RECEPTOR | polymer | 280 | 32155.1 | 1 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (human) | GR |
| 2 | B (A) | 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE | non-polymer | 429.6 | 1 | Chemie (486) PubChem (16394559) PubChem (20651195) PubChem (25260940) PubChem (40785059) PubChem (55245) PubChem (16758830) PubChem (18649237) PubChem (1756360) PubChem (49800048) PubChem (26339468) PubChem (374394) PubChem (73897308) PubChem (70407138) PubChem (4196) PubChem (6604445) PubChem (124300838) PubChem (124404360) PubChem (9910521) PubChem (6426861) PubChem (6569219) PubChem (6604870) PubChem (6712024) PubChem (7048587) PubChem (7048709) PubChem (7048710) PubChem (11743390) PubChem (10387949) PubChem (124338910) PubChem (13080184) PubChem (13080185) PubChem (13080187) PubChem (130205874) PubChem (131632911) PubChem (133269675) PubChem (133688789) PubChem (138113540) PubChem (139025155) PubChem (145874921) PubChem (170056603) PubChem (170130266) | |||
| 3 | C, D, E (A) | HEXANE-1,6-DIOL | non-polymer | 118.2 | 3 | Chemie (HEZ) PubChem (12374) | |||
| 4 | F (A) | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A: 500 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 498 | - | cloning artifact |
| Ser 499 | - | cloning artifact |
| Asp 517 | Asn 517 | engineered mutation |
| Ser 602 | Phe 602 | engineered mutation |
| Asp 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32155.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 784.1 | |
| All* | Total formula weight | 32939.2 |
