1NDO

NAPHTHALENE 1,2-DIOXYGENASE

Summary for 1NDO

• Entry DOI: 10.2210/pdb1ndo/pdb
• Descriptor: NAPHTHALENE 1,2-DIOXYGENASE, FE (III) ION, FE2/S2 (INORGANIC) CLUSTER, ... (5 entities in total)
• Functional Keywords: non-heme iron dioxygenase
• Biological source: Pseudomonas putida; More
• Total number of polymer chains: 6
• Total formula weight: 218595.32

Authors

Ramaswamy, S.,Kauppi, B.,Carredano, E. (deposition date: 1998-01-11, release date: 1999-03-23, Last modification date: 2024-02-14)

Primary citation

Kauppi, B.,Lee, K.,Carredano, E.,Parales, R.E.,Gibson, D.T.,Eklund, H.,Ramaswamy, S.
Structure of an aromatic-ring-hydroxylating dioxygenase-naphthalene 1,2-dioxygenase.
Structure, 6:571-586, 1998

PubMed Abstract: Pseudomonas sp. NCIB 9816-4 utilizes a multicomponent enzyme system to oxidize naphthalene to (+)-cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. The enzyme component catalyzing this reaction, naphthalene 1,2-dioxygenase (NDO), belongs to a family of aromatic-ring-hydroxylating dioxygenases that oxidize aromatic hydrocarbons and related compounds to cis-arene diols. These enzymes utilize a mononuclear non-heme iron center to catalyze the addition of dioxygen to their respective substrates. The present study was conducted to provide essential structural information necessary for elucidating the mechanism of action of NDO.

PubMed: 9634695
DOI: 10.1016/S0969-2126(98)00059-8

Experimental method

X-RAY DIFFRACTION (2.25 Å)