Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1NDO

NAPHTHALENE 1,2-DIOXYGENASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0016491	molecular_function	oxidoreductase activity
A	0018625	molecular_function	naphthalene 1,2-dioxygenase activity
A	0019439	biological_process	obsolete aromatic compound catabolic process
A	0044237	biological_process	cellular metabolic process
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
B	0005515	molecular_function	protein binding
B	0006725	biological_process	obsolete cellular aromatic compound metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0019380	biological_process	3-phenylpropionate catabolic process
B	0019439	biological_process	obsolete aromatic compound catabolic process
B	0051213	molecular_function	dioxygenase activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0016491	molecular_function	oxidoreductase activity
C	0018625	molecular_function	naphthalene 1,2-dioxygenase activity
C	0019439	biological_process	obsolete aromatic compound catabolic process
C	0044237	biological_process	cellular metabolic process
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051537	molecular_function	2 iron, 2 sulfur cluster binding
D	0005515	molecular_function	protein binding
D	0006725	biological_process	obsolete cellular aromatic compound metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0019380	biological_process	3-phenylpropionate catabolic process
D	0019439	biological_process	obsolete aromatic compound catabolic process
D	0051213	molecular_function	dioxygenase activity
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0016491	molecular_function	oxidoreductase activity
E	0018625	molecular_function	naphthalene 1,2-dioxygenase activity
E	0019439	biological_process	obsolete aromatic compound catabolic process
E	0044237	biological_process	cellular metabolic process
E	0046872	molecular_function	metal ion binding
E	0051213	molecular_function	dioxygenase activity
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0005515	molecular_function	protein binding
F	0006725	biological_process	obsolete cellular aromatic compound metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0019380	biological_process	3-phenylpropionate catabolic process
F	0019439	biological_process	obsolete aromatic compound catabolic process
F	0051213	molecular_function	dioxygenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FE A 452

Chain	Residue
A	HIS208
A	HIS213
A	ASP362

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE C 452

Chain	Residue
C	ASN201
C	HIS208
C	HIS213
C	ASP362

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FE E 452

Chain	Residue
E	HIS208
E	HIS213
E	ASP362

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES A 451

Chain	Residue
A	CYS81
A	HIS83
A	ARG84
A	CYS101
A	TYR103
A	HIS104
A	TRP106

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES C 451

Chain	Residue
C	CYS81
C	HIS83
C	ARG84
C	CYS101
C	TYR103
C	HIS104
C	TRP106

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES E 451

Chain	Residue
E	CYS81
E	HIS83
E	ARG84
E	CYS101
E	TYR103
E	HIS104
E	TRP106

site_id	MO1
Number of Residues	3
Details	MONO IRON SITE - THERE IS ALSO A WATER.

Chain	Residue
A	HIS213
A	HIS208
A	ASP362

site_id	MO2
Number of Residues	3
Details	MONO IRON SITE - THERE IS ALSO A WATER.

Chain	Residue
C	ASP362
C	HIS213
C	HIS208

site_id	MO3
Number of Residues	3
Details	MONO IRON SITE - THERE IS ALSO A WATER.

Chain	Residue
E	HIS213
E	HIS208
E	ASP362

site_id	RK1
Number of Residues	4
Details	RIESKE CENTER - FIRST TWO ARE LIGANDS TO FE1 AND THE NEXT TO FE2.

Chain	Residue
A	CYS81
A	CYS101
A	HIS83
C	HIS104

site_id	RK2
Number of Residues	4
Details	RIESKE CENTER - FIRST TWO ARE LIGANDS TO FE1 AND THE NEXT TO FE2.

Chain	Residue
C	CYS81
C	CYS101
C	HIS83
C	HIS104

site_id	RK3
Number of Residues	4
Details	RIESKE CENTER - FIRST TWO ARE LIGANDS TO FE1 AND THE NEXT TO FE2.

Chain	Residue
E	CYS81
E	CYS101
E	HIS83
E	HIS104

Functional Information from PROSITE/UniProt

site_id	PS00570
Number of Residues	24
Details	RING_HYDROXYL_ALPHA Bacterial ring hydroxylating dioxygenases alpha-subunit signature. CrHRGktlvsveaGNakgfvCsYH

Chain	Residue	Details
A	CYS81-HIS104

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269\|PubMed:10669618, ECO:0000269\|PubMed:12586937, ECO:0000269\|PubMed:15942729, ECO:0000269\|PubMed:9634695, ECO:0007744\|PDB:1EG9, ECO:0007744\|PDB:1NDO, ECO:0007744\|PDB:1O7G, ECO:0007744\|PDB:1O7H, ECO:0007744\|PDB:1O7M, ECO:0007744\|PDB:1O7N, ECO:0007744\|PDB:1O7P, ECO:0007744\|PDB:1O7W, ECO:0007744\|PDB:1UUV, ECO:0007744\|PDB:1UUW

Chain	Residue	Details
A	CYS81
C	HIS104
C	HIS208
C	HIS213
E	CYS81
E	HIS83
E	CYS101
E	HIS104
E	HIS208
E	HIS213
A	HIS83
A	CYS101
A	HIS104
A	HIS208
A	HIS213
C	CYS81
C	HIS83
C	CYS101

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:10669618, ECO:0000269\|PubMed:12586937, ECO:0000269\|PubMed:15942729, ECO:0000269\|PubMed:9634695, ECO:0007744\|PDB:1EG9, ECO:0007744\|PDB:1NDO, ECO:0007744\|PDB:1O7G, ECO:0007744\|PDB:1O7H, ECO:0007744\|PDB:1O7M, ECO:0007744\|PDB:1O7N, ECO:0007744\|PDB:1O7P, ECO:0007744\|PDB:1O7W, ECO:0007744\|PDB:1UUV

Chain	Residue	Details
A	ASP362
C	ASP362
E	ASP362

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Important for enantioselectivity => ECO:0000269\|PubMed:10692370

Chain	Residue	Details
A	PHE352
C	PHE352
E	PHE352

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 130

Chain	Residue	Details
A	HIS104	single electron acceptor, single electron donor, single electron relay
A	ASP205	single electron acceptor, single electron donor, single electron relay
A	HIS208	metal ligand, single electron acceptor, single electron donor, single electron relay
A	HIS213	metal ligand
A	ASP362	metal ligand

site_id	MCSA2
Number of Residues	5
Details	M-CSA 130

Chain	Residue	Details
C	HIS104	single electron acceptor, single electron donor, single electron relay
C	ASP205	single electron acceptor, single electron donor, single electron relay
C	HIS208	metal ligand, single electron acceptor, single electron donor, single electron relay
C	HIS213	metal ligand
C	ASP362	metal ligand

site_id	MCSA3
Number of Residues	5
Details	M-CSA 130

Chain	Residue	Details
E	HIS104	single electron acceptor, single electron donor, single electron relay
E	ASP205	single electron acceptor, single electron donor, single electron relay
E	HIS208	metal ligand, single electron acceptor, single electron donor, single electron relay
E	HIS213	metal ligand
E	ASP362	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)