1MU8
thrombin-hirugen_l-378,650
Summary for 1MU8
Entry DOI | 10.2210/pdb1mu8/pdb |
Related | 1MU6 1MUE |
Descriptor | THROMBIN, HIRUDIN IIB, 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-3-METHYL-6-PYRIDINYL)METHYL]ACETAMIDE, ... (5 entities in total) |
Functional Keywords | thrombin-hirugen, blood clotting, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P28506 |
Total number of polymer chains | 3 |
Total formula weight | 35816.72 |
Authors | Burgey, C.S.,Robinson, K.A.,Lyle, T.A.,Sanderson, P.E.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Singh, R.,Miller-Stein, C.,White, R.B.,Wong, B.,Lyle, E.A.,Williams, P.D.,Coburn, C.A.,Dorsey, B.D.,Barrow, J.C.,Stranieri, M.T.,Holahan, M.A.,Sitko, G.R.,Cook, J.J.,McMasters, D.R.,McDonough, C.M.,Sanders, W.M.,Wallace, A.A.,Clayton, F.C.,Bohn, D.,Leonard, Y.M.,Detwiler Jr., T.J.,Lynch Jr., J.J.,Yan, Y.,Chen, Z.,Kuo, L.,Gardell, S.J.,Shafer, J.A.,Vacca, J.P.J. (deposition date: 2002-09-23, release date: 2004-04-06, Last modification date: 2021-07-21) |
Primary citation | Burgey, C.S.,Robinson, K.A.,Lyle, T.A.,Sanderson, P.E.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Singh, R.,Miller-Stein, C.,White, R.B.,Wong, B.,Lyle, E.A.,Williams, P.D.,Coburn, C.A.,Dorsey, B.D.,Barrow, J.C.,Stranieri, M.T.,Holahan, M.A.,Sitko, G.R.,Cook, J.J.,McMasters, D.R.,McDonough, C.M.,Sanders, W.M.,Wallace, A.A.,Clayton, F.C.,Bohn, D.,Leonard, Y.M.,Detwiler Jr., T.J.,Lynch Jr., J.J.,Yan, Y.,Chen, Z.,Kuo, L.,Gardell, S.J.,Shafer, J.A.,Vacca, J.P.J. Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines. J.Med.Chem., 46:461-473, 2003 Cited by PubMed: 12570369DOI: 10.1021/jm020311f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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