1MU8

thrombin-hirugen_l-378,650

Summary for 1MU8
Related1MU6 1MUE
DescriptorTHROMBIN, HIRUDIN IIB, 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-3-METHYL-6-PYRIDINYL)METHYL]ACETAMIDE, ... (5 entities in total)
Functional Keywordsthrombin-hirugen, blood clotting, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted, extracellular space: P00734 P00734
Secreted: P28506
Total number of polymer chains3
Total formula weight35816.72
Authors
Primary citationBarrow, J.C.,Bohn, D.,Burgey, C.S.,Chen, Z.,Clayton, F.C.,Coburn, C.A.,Cook, J.J.,Detwiler Jr., T.J.,Dorsey, B.D.,Gardell, S.J.,Holahan, M.A.,Krueger, J.A.,Kuo, L.,Leonard, Y.M.,Lewis, S.D.,Lucas, B.J.,Lyle, E.A.,Lyle, T.A.,Lynch Jr., J.J.,McDonough, C.M.,McMasters, D.R.,Miller-Stein, C.,Robinson, K.A.,Sanders, W.M.,Sanderson, P.E.,Shafer, J.A.,Singh, R.,Sitko, G.R.,Stranieri, M.T.,Vacca, J.P.J.,Wallace, A.A.,White, R.B.,Williams, P.D.,Wong, B.,Yan, Y.
Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.
J.Med.Chem., 46:461-473, 2003
PubMed: 12570369
DOI: 110.1021/jm020311f
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB Foundation
wwPDBRCSB PDBPDBeBMRBAdv. SearchSearch help

179210

PDB entries from 2021-06-23