1MS7

X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.97 A resolution, Crystallization in the presence of zinc acetate

1MS7 の概要

• エントリーDOI: 10.2210/pdb1ms7/pdb
• 関連するPDBエントリー: 1FTJ 1FTK 1FTL 1FTM 1FTO 1FWO 1GR2 1LB8 1LB9 1LBB 1LBC 1M5B 1M5C 1M5D 1M5E 1M5F 1MM6 1MM7
• 分子名称: Glutamate receptor subunit 2, ZINC ION, (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID, ... (4 entities in total)
• 機能のキーワード: ionotropic glutamate receptor glur2, ligand-binding core, agonist complex, membrane protein
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 88573.92

構造登録者

Kasper, C.,Lunn, M.-L.,Liljefors, T.,Gouaux, E.,Egebjerg, J.,Kastrup, J.S. (登録日: 2002-09-19, 公開日: 2003-07-08, 最終更新日: 2023-10-25)

• 主引用文献: Kasper, C.,Lunn, M.-L.,Liljefors, T.,Gouaux, E.,Egebjerg, J.,Kastrup, J.S.; GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists; FEBS Lett., 531:173-178, 2002; PubMed: 12417307; DOI: 10.1016/S0014-5793(02)03496-8

実験手法

X-RAY DIFFRACTION (1.97 Å)