1MS7

X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.97 A resolution, Crystallization in the presence of zinc acetate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 3001

Chain	Residue
A	HIS20
A	GLU21
B	HIS20
B	GLU27
B	HOH3424

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 3002

Chain	Residue
A	HOH3223
A	HOH3333
A	GLU39
A	LYS42
A	HIS43
A	HOH3184

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 3003

Chain	Residue
A	ASP62
A	HOH3076
A	HOH3326
C	HIS20

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN B 3004

Chain	Residue
B	GLU39
B	HIS43
B	LEU238
B	GLN241
B	HOH3453
C	GLU163

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 3005

Chain	Residue
B	ZN3006
B	HOH3438
B	HOH3439

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 3006

Chain	Residue
B	GLU163
B	ZN3005
C	GLU39
C	HIS43

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SHI A 2001

Chain	Residue
A	TYR58
A	PRO86
A	THR88
A	ARG93
A	GLY138
A	SER139
A	THR140
A	LEU189
A	GLU190
A	MET193
A	TYR217
A	HOH3006
A	HOH3019
A	HOH3070

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SHI B 2002

Chain	Residue
B	TYR58
B	PRO86
B	THR88
B	ARG93
B	GLY138
B	SER139
B	THR140
B	LEU189
B	GLU190
B	MET193
B	TYR217
B	HOH3015
B	HOH3124
B	HOH3446

---

site_id	AC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SHI C 2003

Chain	Residue
C	TYR58
C	PRO86
C	THR88
C	ARG93
C	GLY138
C	SER139
C	THR140
C	LEU189
C	GLU190
C	MET193
C	TYR217
C	HOH2042
C	HOH2378
C	HOH2384

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO86
B	SER139
B	THR140
B	GLU190
C	PRO86
C	THR88
C	ARG93
C	SER139
C	THR140
C	GLU190
A	THR88
A	ARG93
A	SER139
A	THR140
A	GLU190
B	PRO86
B	THR88
B	ARG93

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG61
A	ARG145
A	LYS237
B	ARG61
B	ARG145
B	LYS237
C	ARG61
C	ARG145
C	LYS237

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE118
B	ILE118
C	ILE118

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER147
B	SER147
C	SER147

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER181
B	SER181
C	SER181

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN0
B	ASN0
C	ASN0

---