1MS7
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.97 A resolution, Crystallization in the presence of zinc acetate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 3001 |
| Chain | Residue |
| A | HIS20 |
| A | GLU21 |
| B | HIS20 |
| B | GLU27 |
| B | HOH3424 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 3002 |
| Chain | Residue |
| A | HOH3223 |
| A | HOH3333 |
| A | GLU39 |
| A | LYS42 |
| A | HIS43 |
| A | HOH3184 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 3003 |
| Chain | Residue |
| A | ASP62 |
| A | HOH3076 |
| A | HOH3326 |
| C | HIS20 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 3004 |
| Chain | Residue |
| B | GLU39 |
| B | HIS43 |
| B | LEU238 |
| B | GLN241 |
| B | HOH3453 |
| C | GLU163 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 3005 |
| Chain | Residue |
| B | ZN3006 |
| B | HOH3438 |
| B | HOH3439 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 3006 |
| Chain | Residue |
| B | GLU163 |
| B | ZN3005 |
| C | GLU39 |
| C | HIS43 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SHI A 2001 |
| Chain | Residue |
| A | TYR58 |
| A | PRO86 |
| A | THR88 |
| A | ARG93 |
| A | GLY138 |
| A | SER139 |
| A | THR140 |
| A | LEU189 |
| A | GLU190 |
| A | MET193 |
| A | TYR217 |
| A | HOH3006 |
| A | HOH3019 |
| A | HOH3070 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SHI B 2002 |
| Chain | Residue |
| B | TYR58 |
| B | PRO86 |
| B | THR88 |
| B | ARG93 |
| B | GLY138 |
| B | SER139 |
| B | THR140 |
| B | LEU189 |
| B | GLU190 |
| B | MET193 |
| B | TYR217 |
| B | HOH3015 |
| B | HOH3124 |
| B | HOH3446 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SHI C 2003 |
| Chain | Residue |
| C | TYR58 |
| C | PRO86 |
| C | THR88 |
| C | ARG93 |
| C | GLY138 |
| C | SER139 |
| C | THR140 |
| C | LEU189 |
| C | GLU190 |
| C | MET193 |
| C | TYR217 |
| C | HOH2042 |
| C | HOH2378 |
| C | HOH2384 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
