1MQD

X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate.

Summary for 1MQD

Entry DOI	10.2210/pdb1mqd/pdb
Related	1FTJ 1FTK 1FTL 1FTM 1FTO 1FW0 1GR2 1LB8 1LB9 1LBB 1LBC 1M5B 1M5C 1M5D 1M5E 1M5F 1MM6 1MM7
Descriptor	Glutamate receptor subunit 2, SULFATE ION, (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID, ... (5 entities in total)
Functional Keywords	ionotropic glutamate receptor glur2, ligand-binding core, agonist complex., membrane protein
Biological source	Rattus norvegicus (Norway rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	4
Total formula weight	117379.05
Authors	Kasper, C.,Lunn, M.-L.,Liljefors, T.,Gouaux, E.,Egebjerg, J.,Kastrup, J.S. (deposition date: 2002-09-16, release date: 2003-07-01, Last modification date: 2023-10-25)
Primary citation	Kasper, C.,Lunn, M.L.,Liljefors, T.,Gouaux, E.,Egebjerg, J.,Kastrup, J.S. GluR2 ligand-binding core complexes: Importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists. FEBS Lett., 531:173-178, 2002 Cited by PubMed: 12417307 DOI: 10.1016/S0014-5793(02)03496-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.46 Å)

Structure validation