1MQD

X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 4001

Chain	Residue
B	ARG145
B	TRP156
B	HOH4048
B	HOH4284
D	LYS180
D	HOH4380

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 4002

Chain	Residue
A	HOH4438
C	HIS20
C	GLU21
C	HOH3469
A	ARG145
A	ARG160
A	HOH4195

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 4003

Chain	Residue
A	ARG169
D	ARG145
D	TRP156
D	ARG160
D	HOH4475

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SHI A 3001

Chain	Residue
A	TYR58
A	PRO86
A	THR88
A	ARG93
A	GLY138
A	SER139
A	THR140
A	GLU190
A	MET193
A	TYR217
A	HOH4006
A	HOH4028
A	HOH4686

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SHI B 3002

Chain	Residue
B	TYR58
B	PRO86
B	THR88
B	ARG93
B	GLY138
B	SER139
B	THR140
B	GLU190
B	MET193
B	TYR217
B	HOH4004
B	HOH4015
B	HOH4121

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SHI C 3003

Chain	Residue
C	TYR58
C	PRO86
C	THR88
C	ARG93
C	GLY138
C	SER139
C	THR140
C	GLU190
C	MET193
C	HOH3010
C	HOH3026
C	HOH3118

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SHI D 3004

Chain	Residue
D	TYR58
D	PRO86
D	THR88
D	ARG93
D	GLY138
D	SER139
D	THR140
D	GLU190
D	MET193
D	TYR217
D	HOH4011
D	HOH4012
D	HOH4053

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 3230

Chain	Residue
A	ASN211
A	ASP213
A	SER214
A	HOH4117

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
C	PRO86
C	THR88
C	ARG93
C	SER139
C	THR140
C	GLU190
D	PRO86
D	THR88
D	ARG93
D	SER139
D	THR140
D	GLU190
A	PRO86
B	SER139
B	THR140
B	GLU190
A	THR88
A	ARG93
A	SER139
A	THR140
A	GLU190
B	PRO86
B	THR88
B	ARG93

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
D	ARG61
D	ARG145
D	LYS237
B	ARG145
B	LYS237
C	ARG61
C	ARG145
C	LYS237
A	ARG61
A	ARG145
A	LYS237
B	ARG61

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE118
B	ILE118
C	ILE118
D	ILE118

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER147
B	SER147
C	SER147
D	SER147

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER181
C	SER181
D	SER181
B	SER181

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN0
C	ASN0
D	ASN0
B	ASN0

---