1MQD
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 4001 |
| Chain | Residue |
| B | ARG145 |
| B | TRP156 |
| B | HOH4048 |
| B | HOH4284 |
| D | LYS180 |
| D | HOH4380 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 4002 |
| Chain | Residue |
| A | HOH4438 |
| C | HIS20 |
| C | GLU21 |
| C | HOH3469 |
| A | ARG145 |
| A | ARG160 |
| A | HOH4195 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 4003 |
| Chain | Residue |
| A | ARG169 |
| D | ARG145 |
| D | TRP156 |
| D | ARG160 |
| D | HOH4475 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SHI A 3001 |
| Chain | Residue |
| A | TYR58 |
| A | PRO86 |
| A | THR88 |
| A | ARG93 |
| A | GLY138 |
| A | SER139 |
| A | THR140 |
| A | GLU190 |
| A | MET193 |
| A | TYR217 |
| A | HOH4006 |
| A | HOH4028 |
| A | HOH4686 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SHI B 3002 |
| Chain | Residue |
| B | TYR58 |
| B | PRO86 |
| B | THR88 |
| B | ARG93 |
| B | GLY138 |
| B | SER139 |
| B | THR140 |
| B | GLU190 |
| B | MET193 |
| B | TYR217 |
| B | HOH4004 |
| B | HOH4015 |
| B | HOH4121 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SHI C 3003 |
| Chain | Residue |
| C | TYR58 |
| C | PRO86 |
| C | THR88 |
| C | ARG93 |
| C | GLY138 |
| C | SER139 |
| C | THR140 |
| C | GLU190 |
| C | MET193 |
| C | HOH3010 |
| C | HOH3026 |
| C | HOH3118 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SHI D 3004 |
| Chain | Residue |
| D | TYR58 |
| D | PRO86 |
| D | THR88 |
| D | ARG93 |
| D | GLY138 |
| D | SER139 |
| D | THR140 |
| D | GLU190 |
| D | MET193 |
| D | TYR217 |
| D | HOH4011 |
| D | HOH4012 |
| D | HOH4053 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 3230 |
| Chain | Residue |
| A | ASN211 |
| A | ASP213 |
| A | SER214 |
| A | HOH4117 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
