1M4U
Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin
Summary for 1M4U
Entry DOI | 10.2210/pdb1m4u/pdb |
Related | 1BMP 1ES7 3BMP |
Descriptor | Bone Morphogenetic Protein-7, Noggin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | noggin, bmp antagonist, bmp-7, bone morphogenetic protein, cystine knot, hormone-growth factor complex, hormone/growth factor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P18075 Q13253 |
Total number of polymer chains | 2 |
Total formula weight | 39336.98 |
Authors | Groppe, J.,Greenwald, J.,Wiater, E.,Rodriguez-Leon, J.,Economides, A.N.,Kwiatkowski, W.,Affolter, M.,Vale, W.W.,Izpisua-Belmonte, J.C.,Choe, S. (deposition date: 2002-07-03, release date: 2002-12-18, Last modification date: 2022-12-21) |
Primary citation | Groppe, J.,Greenwald, J.,Wiater, E.,Rodriguez-Leon, J.,Economides, A.N.,Kwiatkowski, W.,Affolter, M.,Vale, W.W.,Izpisua-Belmonte, J.C.,Choe, S. Structural Basis of BMP Signalling Inhibition by the Cystine Knot Protein Noggin Nature, 420:636-642, 2002 Cited by PubMed: 12478285DOI: 10.1038/nature01245 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.42 Å) |
Structure validation
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