1M48
Crystal Structure of Human IL-2 Complexed with (R)-N-[2-[1-(Aminoiminomethyl)-3-piperidinyl]-1-oxoethyl]-4-(phenylethynyl)-L-phenylalanine methyl ester
Summary for 1M48
Entry DOI | 10.2210/pdb1m48/pdb |
Related | 1m47 1M49 1M4A 1M4B 1M4C |
Descriptor | interleukin-2, 2-[3-METHYL-4-(N-METHYL-GUANIDINO)-BUTYRYLAMINO]-3-(4-PHENYLETHYNYL-PHENYL)-PROPIONIC ACID METHYL ESTER (3 entities in total) |
Functional Keywords | interleukin-2, four-helix bundle, small molecule complex, cytokine |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P60568 |
Total number of polymer chains | 2 |
Total formula weight | 31765.04 |
Authors | Arkin, M.A.,Randal, M.,DeLano, W.L.,Hyde, J.,Luong, T.N.,Oslob, J.D.,Raphael, D.R.,Taylor, L.,Wang, J.,McDowell, R.S.,Wells, J.A.,Braisted, A.C. (deposition date: 2002-07-02, release date: 2002-07-31, Last modification date: 2017-10-11) |
Primary citation | Arkin, M.A.,Randal, M.,DeLano, W.L.,Hyde, J.,Luong, T.N.,Oslob, J.D.,Raphael, D.R.,Taylor, L.,Wang, J.,McDowell, R.S.,Wells, J.A.,Braisted, A.C. Binding of small molecules to an adaptive protein-protein interface Proc.Natl.Acad.Sci.USA, 100:1603-1608, 2003 Cited by PubMed: 12582206DOI: 10.1073/pnas.252756299 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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