1M04
Mutant Streptomyces plicatus beta-hexosaminidase (D313N) in complex with product (GlcNAc)
Summary for 1M04
Entry DOI | 10.2210/pdb1m04/pdb |
Related | 1hp5 1jak 1M01 1M03 |
Descriptor | Beta-N-acetylhexosaminidase, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | substrate assisted catalysis, hexosaminidase, family 20 glycosidase, hydrolase |
Biological source | Streptomyces plicatus |
Total number of polymer chains | 1 |
Total formula weight | 56641.52 |
Authors | Williams, S.J.,Mark, B.L.,Vocadlo, D.J.,James, M.N.G.,Withers, S.G. (deposition date: 2002-06-11, release date: 2002-12-11, Last modification date: 2021-10-27) |
Primary citation | Williams, S.J.,Mark, B.L.,Vocadlo, D.J.,James, M.N.,Withers, S.G. Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state. J.Biol.Chem., 277:40055-40065, 2002 Cited by PubMed: 12171933DOI: 10.1074/jbc.M206481200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
Download full validation report