1LBC

Crystal structure of GluR2 ligand binding core (S1S2J-N775S) in complex with cyclothiazide (CTZ) as well as glutamate at 1.8 A resolution

Summary for 1LBC

• Entry DOI: 10.2210/pdb1lbc/pdb
• Related: 1FTJ 1LB8 1LB9 1LBB
• Descriptor: Glutamine Receptor 2, ZINC ION, GLUTAMIC ACID, ... (5 entities in total)
• Functional Keywords: ampa receptor, glur2, s1s2, ligand binding core, point mutation, n775s, cyclothiazide, ctz, agonist, membrane protein
• Biological source: Rattus norvegicus (Norway rat)
• Cellular location: Cell membrane; Multi-pass membrane protein: 1LBC
• Total number of polymer chains: 3
• Total formula weight: 89522.04

Authors

Sun, Y.,Olson, R.,Horning, M.,Armstrong, N.,Mayer, M.,Gouaux, E. (deposition date: 2002-04-02, release date: 2002-05-29, Last modification date: 2023-08-16)

• Primary citation: Sun, Y.,Olson, R.,Horning, M.,Armstrong, N.,Mayer, M.,Gouaux, E.; Mechanism of glutamate receptor desensitization.; Nature, 417:245-253, 2002; PubMed: 12015593; DOI: 10.1038/417245a

Experimental method

X-RAY DIFFRACTION (1.8 Å)