1KZK

JE-2147-HIV Protease Complex

1KZK の概要

• エントリーDOI: 10.2210/pdb1kzk/pdb
• 関連するPDBエントリー: 1hpx
• 関連するBIRD辞書のPRD_ID: PRD_000566
• 分子名称: Protease, (4R)-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: hiv protease complex, anisotropic displacement parameters, viral protein, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22666.85

構造登録者

Reiling, K.K.,Endres, N.F.,Dauber, D.S.,Craik, C.S.,Stroud, R.M. (登録日: 2002-02-06, 公開日: 2002-04-03, 最終更新日: 2023-08-16)

• 主引用文献: Reiling, K.K.,Endres, N.F.,Dauber, D.S.,Craik, C.S.,Stroud, R.M.; Anisotropic Dynamics of the JE-2147-HIV Protease Complex: Drug Resistance and Thermodynamic Binding Mode Examined in a 1.09 A Structure; Biochemistry, 41:4582-4594, 2002; PubMed: 11926820; DOI: 10.1021/bi011781z

実験手法

X-RAY DIFFRACTION (1.09 Å)