1KCQ

Human Gelsolin Domain 2 with a Cd2+ bound

Summary for 1KCQ

Entry DOI	10.2210/pdb1kcq/pdb
Descriptor	GELSOLIN, CADMIUM ION (3 entities in total)
Functional Keywords	alpha-beta structure, actin-binding protein, familial amyloidosis--finnish type, cadmium binding, metal binding, structural protein
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm, cytoskeleton. Isoform 1: Secreted: P06396
Total number of polymer chains	1
Total formula weight	12042.61
Authors	Kazmirski, S.L.,Isaacson, R.L.,An, C.,Buckle, A.,Johnson, C.M.,Daggett, V.,Fersht, A.R. (deposition date: 2001-11-09, release date: 2002-01-04, Last modification date: 2023-08-16)
Primary citation	Kazmirski, S.L.,Isaacson, R.L.,An, C.,Buckle, A.,Johnson, C.M.,Daggett, V.,Fersht, A.R. Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type. Nat.Struct.Biol., 9:112-116, 2002 Cited by PubMed: 11753432 DOI: 10.1038/nsb745 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation