1KCQ
Human Gelsolin Domain 2 with a Cd2+ bound
Summary for 1KCQ
Entry DOI | 10.2210/pdb1kcq/pdb |
Descriptor | GELSOLIN, CADMIUM ION (3 entities in total) |
Functional Keywords | alpha-beta structure, actin-binding protein, familial amyloidosis--finnish type, cadmium binding, metal binding, structural protein |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 2: Cytoplasm, cytoskeleton. Isoform 1: Secreted: P06396 |
Total number of polymer chains | 1 |
Total formula weight | 12042.61 |
Authors | Kazmirski, S.L.,Isaacson, R.L.,An, C.,Buckle, A.,Johnson, C.M.,Daggett, V.,Fersht, A.R. (deposition date: 2001-11-09, release date: 2002-01-04, Last modification date: 2023-08-16) |
Primary citation | Kazmirski, S.L.,Isaacson, R.L.,An, C.,Buckle, A.,Johnson, C.M.,Daggett, V.,Fersht, A.R. Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type. Nat.Struct.Biol., 9:112-116, 2002 Cited by PubMed: 11753432DOI: 10.1038/nsb745 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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