1KBQ

Complex of Human NAD(P)H quinone Oxidoreductase with 5-methoxy-1,2-dimethyl-3-(4-nitrophenoxymethyl)indole-4,7-dione (ES936)

1KBQ の概要

• エントリーDOI: 10.2210/pdb1kbq/pdb
• 関連するPDBエントリー: 1D4A 1GG5 1H66 1H69 1KBO 1QRD
• 分子名称: NAD(P)H dehydrogenase [quinone] 1, FLAVIN-ADENINE DINUCLEOTIDE, 5-METHOXY-1,2-DIMETHYL-3-(4-NITROPHENOXYMETHYL)INDOLE-4,7-DIONE, ... (4 entities in total)
• 機能のキーワード: flavoenzyme, prodrug-enzyme complex, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P15559
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 127673.16

構造登録者

Faig, M.,Bianchet, M.A.,Amzel, L.M. (登録日: 2001-11-06, 公開日: 2002-01-16, 最終更新日: 2023-08-16)

• 主引用文献: Winski, S.L.,Faig, M.,Bianchet, M.A.,Siegel, D.,Swann, E.,Fung, K.,Duncan, M.W.,Moody, C.J.,Amzel, L.M.,Ross, D.; Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches.; Biochemistry, 40:15135-15142, 2001; PubMed: 11735396; DOI: 10.1021/bi011324i

実験手法

X-RAY DIFFRACTION (1.8 Å)