1JL0

Structure of a Human S-Adenosylmethionine Decarboxylase Self-processing Ester Intermediate and Mechanism of Putrescine Stimulation of Processing as Revealed by the H243A Mutant

Summary for 1JL0

• Entry DOI: 10.2210/pdb1jl0/pdb
• Related: 1JEN
• Descriptor: S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME, 1,4-DIAMINOBUTANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• Functional Keywords: spermidine biosynthesis, lyase, decarboxylase, pyruvate, s-adenosylmethionine, sandwich, allosteric enzyme, pyruvoyl, ester intermediate, hydroxyalanine
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 77017.49

Authors

Ekstrom, J.L.,Tolbert, W.D.,Xiong, H.,Pegg, A.E.,Ealick, S.E. (deposition date: 2001-07-13, release date: 2001-08-22, Last modification date: 2023-08-16)

• Primary citation: Ekstrom, J.L.,Tolbert, W.D.,Xiong, H.,Pegg, A.E.,Ealick, S.E.; Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant.; Biochemistry, 40:9495-9504, 2001; PubMed: 11583148; DOI: 10.1021/bi010736o

Experimental method

X-RAY DIFFRACTION (1.5 Å)