1JCS

CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE PEPTIDE SUBSTRATE TKCVFM AND AN ANALOG OF FARNESYL DIPHOSPHATE

Summary for 1JCS

• Entry DOI: 10.2210/pdb1jcs/pdb
• Related: 1D8D 1FT1 1JCQ 1JCR
• Descriptor: PROTEIN FARNESYLTRANSFERASE, ALPHA SUBUNIT, PROTEIN FARNESYLTRANSFERASE, BETA SUBUNIT, SYNTHETIC HEXAPEPTIDE TKCVFM, ... (7 entities in total)
• Functional Keywords: ftase, pft, pftase, ft, fpt, farnesyltransferase, farnesyl transferase, farnesyl protein transferase, caax, ras, cancer, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 3
• Total formula weight: 94094.28

Authors

Long, S.B.,Casey, P.J.,Beese, L.S. (deposition date: 2001-06-11, release date: 2001-11-02, Last modification date: 2023-08-16)

• Primary citation: Long, S.B.,Hancock, P.J.,Kral, A.M.,Hellinga, H.W.,Beese, L.S.; The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.; Proc.Natl.Acad.Sci.USA, 98:12948-12953, 2001; PubMed: 11687658; DOI: 10.1073/pnas.241407898

Experimental method

X-RAY DIFFRACTION (2.2 Å)