1IZH

Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants

Summary for 1IZH

• Entry DOI: 10.2210/pdb1izh/pdb
• Related: 1IZI
• Descriptor: proteinase, {(1S)-1-BENZYL-4-[3-CARBAMOYL-1-(1-CARBAMOYL-2-PHENYL-ETHYLCARBAMOYL)-(S)-PROPYLCARBAMOYL]-2-OXO-5-PHENYL-PENTYL}-CARBAMIC ACID TERT-BUTYL ESTER (3 entities in total)
• Functional Keywords: hiv-1 proteinase, potent inhibitor, subsite binding, hydrolase
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22347.37

Authors

Weber, J.,Mesters, J.R.,Lepsik, M.,Prejdova, J.,Svec, M.,Sponarova, J.,Mlcochova, P.,Skalicka, K.,Strisovsky, K.,Uhlikova, T.,Soucek, M.,Machala, L.,Stankova, M.,Vondrasek, J.,Klimkait, T.,Kraeusslich, H.-G.,Hilgenfeld, R.,Konvalinka, J. (deposition date: 2002-10-02, release date: 2002-12-23, Last modification date: 2023-10-25)

• Primary citation: Weber, J.,Mesters, J.R.,Lepsik, M.,Prejdova, J.,Svec, M.,Sponarova, J.,Mlcochova, P.,Skalicka, K.,Strisovsky, K.,Uhlikova, T.,Soucek, M.,Machala, L.,Stankova, M.,Vondrasek, J.,Klimkait, T.,Kraeusslich, H.-G.,Hilgenfeld, R.,Konvalinka, J.; Unusual Binding Mode of an HIV-1 Protease Inhibitor Explains its Potency against Multi-drug-resistant Virus Strains; J.MOL.BIOL., 324:739-754, 2002; PubMed: 12460574; DOI: 10.1016/S0022-2836(02)01139-7

Experimental method

X-RAY DIFFRACTION (1.9 Å)