1IZI
Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants
Summary for 1IZI
Entry DOI | 10.2210/pdb1izi/pdb |
Related | 1IZH |
Descriptor | proteinase, CHLORIDE ION, {(1S)-1-BENZYL-4-[3-CARBAMOYL-1-(1-CARBAMOYL-2-PHENYL-ETHYLCARBAMOYL)-(S)-PROPYLCARBAMOYL]-2-OXO-5-PHENYL-PENTYL}-CARBAMIC ACID TERT-BUTYL ESTER, ... (4 entities in total) |
Functional Keywords | hiv-1 proteinase, triple mutant, potent inhibitor, subsite binding, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22450.28 |
Authors | Weber, J.,Mesters, J.R.,Lepsik, M.,Prejdova, J.,Svec, M.,Sponarova, J.,Mlcochova, P.,Skalicka, K.,Strisovsky, K.,Uhlikova, T.,Soucek, M.,Machala, L.,Stankova, M.,Vondrasek, J.,Klimkait, T.,Kraeusslich, H.-G.,Hilgenfeld, R.,Konvalinka, J. (deposition date: 2002-10-02, release date: 2002-12-23, Last modification date: 2023-10-25) |
Primary citation | Weber, J.,Mesters, J.R.,Lepsik, M.,Prejdova, J.,Svec, M.,Sponarova, J.,Mlcochova, P.,Skalicka, K.,Strisovsky, K.,Uhlikova, T.,Soucek, M.,Machala, L.,Stankova, M.,Vondrasek, J.,Klimkait, T.,Kraeusslich, H.-G.,Hilgenfeld, R.,Konvalinka, J. Unusual Binding Mode of an HIV-1 Protease Inhibitor Explains its Potency against Multi-drug-resistant Virus Strains J.MOL.BIOL., 324:739-754, 2002 Cited by PubMed: 12460574DOI: 10.1016/S0022-2836(02)01139-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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