1IZI
Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | proteinase | polymer | 99 | 10846.8 | 2 | UniProt (Q90EB9) Pfam (PF00077) UniProt (by SIFTS) (P03367) | Human immunodeficiency virus 1 | protease |
| 2 | C, D (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 3 | E (B) | {(1S)-1-BENZYL-4-[3-CARBAMOYL-1-(1-CARBAMOYL-2-PHENYL-ETHYLCARBAMOYL)-(S)-PROPYLCARBAMOYL]-2-OXO-5-PHENYL-PENTYL}-CARBAMIC ACID TERT-BUTYL ESTER | non-polymer | 685.8 | 1 | Chemie (Q50) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: Q90EB9)
| PDB | External Database | Details |
|---|---|---|
| Val 71 | Ala 71 | engineered mutation |
| Thr 82 | Val 82 | engineered mutation |
| Val 84 | Ile 84 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21693.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 756.7 | |
| All* | Total formula weight | 22450.3 |
