1IKV

K103N Mutant HIV-1 Reverse Transcriptase in Complex with Efivarenz

Summary for 1IKV

Entry DOI	10.2210/pdb1ikv/pdb
Descriptor	POL POLYPROTEIN, (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE (3 entities in total)
Functional Keywords	heterodimer, protein-inhibitor complex, transferase
Biological source	Human immunodeficiency virus 1 More
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
Total number of polymer chains	2
Total formula weight	114728.98
Authors	Lindberg, J.,Unge, T. (deposition date: 2001-05-07, release date: 2001-06-06, Last modification date: 2024-02-07)
Primary citation	Lindberg, J.,Sigurdsson, S.,Lowgren, S.,Andersson, H.O.,Sahlberg, C.,Noreen, R.,Fridborg, K.,Zhang, H.,Unge, T. Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant. Eur.J.Biochem., 269:1670-1677, 2002 Cited by PubMed: 11895437 DOI: 10.1046/j.1432-1327.2002.02811.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation