1HRN

HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS

Summary for 1HRN

DescriptorRENIN, N-ACETYL-D-GLUCOSAMINE, (2R,4S,5S)-N-[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]-2-(cyclopropylmethyl)-4,5-dihydroxy-6-phenylhexanamide, ... (4 entities in total)
Functional Keywordsaspartic proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight75329.03
Authors
Tong, L.,Anderson, P.C. (deposition date: 1995-03-31, release date: 1995-06-03, Last modification date: 2019-07-17)
Primary citation
Tong, L.,Pav, S.,Lamarre, D.,Pilote, L.,LaPlante, S.,Anderson, P.C.,Jung, G.
High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors.
J.Mol.Biol., 250:211-222, 1995
PubMed: 7608971 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.1995.0372
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers21 0.8% 14.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution