1HNZ

STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH HYGROMYCIN B

Summary for 1HNZ

Entry DOI	10.2210/pdb1hnz/pdb
Related	1FJF 1FJG 1HNW 1HNX 1QD7
Descriptor	16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S9, 30S RIBOSOMAL PROTEIN S10, ... (25 entities in total)
Functional Keywords	30s ribosomal subunit, ribosome, antibiotic, hygromycin b
Biological source	Thermus thermophilus More
Total number of polymer chains	22
Total formula weight	788318.49
Authors	Brodersen, D.E.,Clemons Jr., W.M.,Carter, A.P.,Morgan-Warren, R.,Wimberly, B.T.,Ramakrishnan, V. (deposition date: 2000-12-08, release date: 2001-02-21, Last modification date: 2023-08-09)
Primary citation	Brodersen, D.E.,Clemons Jr., W.M.,Carter, A.P.,Morgan-Warren, R.J.,Wimberly, B.T.,Ramakrishnan, V. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell(Cambridge,Mass.), 103:1143-1154, 2000 Cited by PubMed Abstract: We have used the recently determined atomic structure of the 30S ribosomal subunit to determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and hygromycin B. The antibiotics bind to discrete sites on the 30S subunit in a manner consistent with much but not all biochemical data. For each of these antibiotics, interactions with the 30S subunit suggest a mechanism for its effects on ribosome function. PubMed: 11163189 DOI: 10.1016/S0092-8674(00)00216-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation