1HE8

Ras G12V - PI 3-kinase gamma complex

1HE8 の概要

• エントリーDOI: 10.2210/pdb1he8/pdb
• 関連するPDBエントリー: 1E8Y 1E8Z
• 分子名称: PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT, GAMMA ISOFORM, TRANSFORMING PROTEIN P21/H-RAS-1, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: kinase/hydrolase, complex (phosphoinositide kinase-ras), phosphoinositide 3-kinase gamma - h-ras g12v complex, phosphatidylinositol 3-kinase, pi3k, pi 3-k, pi 3-kinase, second messenger generation, ras effector, h-ras g12v, oncogene protein, gmppnp, gtp, ras-binding domain, heat domain, kinase-hydrolase complex
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 130090.72

構造登録者

Pacold, M.E.,Suire, S.,Perisic, O.,Lara-Gonzalez, S.,Davis, C.T.,Hawkins, P.T.,Walker, E.H.,Stephens, L.,Eccleston, J.F.,Williams, R.L. (登録日: 2000-11-20, 公開日: 2001-01-08, 最終更新日: 2023-12-13)

• 主引用文献: Pacold, M.E.,Suire, S.,Perisic, O.,Lara-Gonzalez, S.,Davis, C.T.,Walker, E.H.,Hawkins, P.T.,Stephens, L.,Eccleston, J.F.,Williams, R.L.; Crystal Structure and Functional Analysis of Ras Binding to its Effector Phosphoinositide 3-Kinase Gamma; Cell(Cambridge,Mass.), 103:931-, 2000; PubMed: 11136978; DOI: 10.1016/S0092-8674(00)00196-3

実験手法

X-RAY DIFFRACTION (3 Å)