1HB0

Snapshots of serine protease catalysis: (D) acyl-enzyme intermediate between porcine pancreatic elastase and human beta-casomorphin-7 jumped to pH 10 for 2 minutes

Summary for 1HB0

• Entry DOI: 10.2210/pdb1hb0/pdb
• Related: 1B0E 1BMA 1BTU 1C1M 1E34 1E35 1E36 1E37 1E38 1EAI 1EAS 1EAT 1EAU 1ELA 1ELB 1ELC 1ELD 1ELE 1ELF 1ELG 1ESA 1ESB 1EST 1FLE 1H9L 1HAX 1HAY 1HAZ 1HV7 1INC 1JIM 1LVY 1NES 1QGF 1QIX 1QNJ 1QR3 2EST 3EST 4EST 5EST 6EST 7EST 8EST 9EST
• Descriptor: ELASTASE 1, CALCIUM ION, SULFATE ION, ... (4 entities in total)
• Functional Keywords: hydrolase, serine proteinase, hydrolase (serine proteinase)
• Biological source: SUS SCROFA (PIG)
• Cellular location: Secreted: P00772
• Total number of polymer chains: 1
• Total formula weight: 26150.29

Authors

Wilmouth, R.C.,Edman, K.,Neutze, R.,Wright, P.A.,Clifton, I.J.,Schneider, T.R.,Schofield, C.J.,Hajdu, J. (deposition date: 2001-04-10, release date: 2001-08-02, Last modification date: 2023-12-13)

• Primary citation: Wilmouth, R.C.,Edman, K.,Neutze, R.,Wright, P.A.,Clifton, I.J.,Schneider, T.R.,Schofield, C.J.,Hajdu, J.; X-Ray Snapshots of Serine Protease Catalysis Reveal a Tetrahedral Intermediate; Nat.Struct.Biol., 8:689-, 2001; PubMed: 11473259; DOI: 10.1038/90401

Experimental method

X-RAY DIFFRACTION (2.05 Å)