1H7X
Dihydropyrimidine dehydrogenase (DPD) from pig, ternary complex of a mutant enzyme (C671A), NADPH and 5-fluorouracil
Summary for 1H7X
Entry DOI | 10.2210/pdb1h7x/pdb |
Related | 1H7W |
Descriptor | DIHYDROPYRIMIDINE DEHYDROGENASE, IRON/SULFUR CLUSTER, FLAVIN MONONUCLEOTIDE, ... (7 entities in total) |
Functional Keywords | electron transfer, flavin, iron-sulfur clusters, pyrimidine catabolism, 5-fluorouracil degradation, oxidoreductase |
Biological source | SUS SCROFA (WILD BOAR) |
Cellular location | Cytoplasm: Q28943 |
Total number of polymer chains | 4 |
Total formula weight | 460380.93 |
Authors | Dobritzsch, D.,Schneider, G.,Schnackerz, K.D.,Lindqvist, Y. (deposition date: 2001-01-19, release date: 2001-02-23, Last modification date: 2024-05-01) |
Primary citation | Dobritzsch, D.,Schneider, G.,Schnackerz, K.D.,Lindqvist, Y. Crystal Structure of Dihydropyrimidine Dehydrogenase, a Major Determinant of the Pharmacokinetics of the Anti-Cancer Drug 5-Fluorouracil Embo J., 20:650-, 2001 Cited by PubMed: 11179210DOI: 10.1093/EMBOJ/20.4.650 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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