1H7X
Dihydropyrimidine dehydrogenase (DPD) from pig, ternary complex of a mutant enzyme (C671A), NADPH and 5-fluorouracil
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | DIHYDROPYRIMIDINE DEHYDROGENASE | polymer | 1025 | 111571.3 | 4 | UniProt (Q28943) Pfam (PF14691) Pfam (PF07992) Pfam (PF01180) Pfam (PF14697) | SUS SCROFA (WILD BOAR) | DIHYDROURACIL DEHYDROGENASE, DIHYDROTHYMINE DEHYDROGENASE |
| 2 | CA, DA, E, EA, F... (D, A, B, C) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 16 | Chemie (SF4) | |||
| 3 | GA, I, Q, Y (D, A, B, C) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 4 | Chemie (FMN) | |||
| 4 | HA, J, R, Z (D, A, B, C) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 4 | Chemie (FAD) | |||
| 5 | AA, IA, K, S (C, D, A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
| 6 | BA, JA, L, T (C, D, A, B) | 5-FLUOROURACIL | non-polymer | 130.1 | 4 | Chemie (URF) | |||
| 7 | KA, LA, MA, NA (A, B, C, D) | water | water | 18.0 | 4289 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 1025 (UniProt: Q28943)
| PDB | External Database | Details |
|---|---|---|
| Asp 60 | Gly 60 | conflict |
| Ala 671 | Cys 671 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 446285.1 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 14095.8 | |
| All* | Total formula weight | 460380.9 |
