1H2L
Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide
Summary for 1H2L
Entry DOI | 10.2210/pdb1h2l/pdb |
Related | 1D7G 1H2K 1H2M 1H2N 1L8C 1LM8 1LQB |
Descriptor | FACTOR INHIBITING HIF1, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA, FE (II) ION, ... (6 entities in total) |
Functional Keywords | transcription activator-inhibitor complex, transcription activator inhibitor complex, oxygenase, transcription, hypoxia, asparaginyl hydroxylase, hydroxylase, transcription activator/inhibitor |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm : Q16665 |
Total number of polymer chains | 2 |
Total formula weight | 45229.29 |
Authors | Elkins, J.M.,Hewitson, K.S.,McNeill, L.A.,Schlemminger, I.,Seibel, J.F.,Schofield, C.J. (deposition date: 2002-08-12, release date: 2002-11-28, Last modification date: 2024-05-08) |
Primary citation | Elkins, J.M.,Hewitson, K.S.,McNeill, L.A.,Seibel, J.F.,Schlemminger, I.,Pugh, C.,Ratcliffe, P.,Schofield, C.J. Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha J.Biol.Chem., 278:1802-1806, 2003 Cited by PubMed: 12446723DOI: 10.1074/JBC.C200644200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
Download full validation report