1GWR

HUMAN OESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 17BETA-OESTRADIOL AND TIF2 NRBOX3 PEPTIDE

1GWR の概要

• エントリーDOI: 10.2210/pdb1gwr/pdb
• 関連するPDBエントリー: 1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1HCP 1HCQ 1QKT 1QKU 3ERD 3ERT
• 分子名称: OESTROGEN RECEPTOR, TRANSCRIPTION INTERMEDIARY FACTOR-2, ESTRADIOL, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, transcription factor, transactivation, agonist, af2 coactivator, receptor, activator, transcripti regulation, dna-binding, nuclear protein, zinc finger, ster binding, phosphorylation, polymorphism, alternative splicing
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Isoform 1: Nucleus. Isoform 3: Nucleus: P03372; Nucleus: Q15596
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 58771.40

構造登録者

Pike, A.C.W.,Brzozowski, A.M. (登録日: 2002-03-22, 公開日: 2002-08-29, 最終更新日: 2023-12-13)

• 主引用文献: Warnmark, A.,Treuter, E.,Gustafsson, J.-A.,Hubbard, R.E.,Brzozowski, A.M.,Pike, A.C.W.; Interaction of Transcriptional Intermediary Factor 2 Nuclear Receptor Box Peptides with the Coactivator Binding Site of Estrogen Receptor Alpha.; J.Biol.Chem., 277:21862-, 2002; PubMed: 11937504; DOI: 10.1074/JBC.M200764200

実験手法

X-RAY DIFFRACTION (2.4 Å)