1GS4
Structural basis for the glucocorticoid response in a mutant human androgen receptor (ARccr) derived from an androgen-independent prostate cancer
Summary for 1GS4
Entry DOI | 10.2210/pdb1gs4/pdb |
Related | 1E3G |
Descriptor | ANDROGEN RECEPTOR, 9ALPHA-FLUOROCORTISOL, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | androgen receptor, human androgen receptor, ligand-binding domain, cortisol/ cortisone response, prostate cancer |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus : P10275 |
Total number of polymer chains | 1 |
Total formula weight | 29415.36 |
Authors | Matias, P.M.,Carrondo, M.A.,Coelho, R.,Thomaz, M.,Zhao, X.-Y.,Wegg, A.,Crusius, K.,Egner, U.,Donner, P. (deposition date: 2001-12-27, release date: 2003-01-16, Last modification date: 2023-12-13) |
Primary citation | Matias, P.M.,Carrondo, M.A.,Coelho, R.,Thomaz, M.,Zhao, X.-Y.,Wegg, A.,Crusius, K.,Egner, U.,Donner, P. Structural Basis for the Glucocorticoid Response in a Mutant Human Androgen Receptor (Ar(Ccr)) Derived from an Androgen-Independent Prostate Cancer J.Med.Chem., 45:1439-1446, 2002 Cited by PubMed: 11906285DOI: 10.1021/JM011072J PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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