1GS4
Structural basis for the glucocorticoid response in a mutant human androgen receptor (ARccr) derived from an androgen-independent prostate cancer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ANDROGEN RECEPTOR | polymer | 248 | 28939.9 | 1 | UniProt (P10275) Pfam (PF00104) | HOMO SAPIENS (HUMAN) | |
| 2 | B (A) | 9ALPHA-FLUOROCORTISOL | non-polymer | 380.4 | 1 | Chemie (ZK5) PubChem (31378) PubChem (541123) PubChem (22790932) PubChem (24758427) PubChem (44276952) PubChem (45039263) PubChem (46781594) PubChem (143798153) PubChem (92436528) PubChem (57255214) PubChem (57508753) PubChem (146156834) PubChem (70400740) PubChem (122130697) PubChem (133688374) PubChem (163285195) PubChem (166816697) PubChem (172012057) | |||
| 3 | C (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) PubChem (1061) | |||
| 4 | D (A) | water | water | 18.0 | 106 | Chemie (HOH) |
Sequence modifications
A: 670 - 917 (UniProt: P10275)
| PDB | External Database | Details |
|---|---|---|
| His 701 | Leu 701 | engineered mutation |
| Ala 877 | Thr 877 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28939.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 475.4 | |
| All* | Total formula weight | 29415.4 |
