1GS4
Structural basis for the glucocorticoid response in a mutant human androgen receptor (ARccr) derived from an androgen-independent prostate cancer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ANDROGEN RECEPTOR | polymer | 248 | 28939.9 | 1 | UniProt (P10275) Pfam (PF00104) In PDB | HOMO SAPIENS (HUMAN) | |
| 2 | A | 9ALPHA-FLUOROCORTISOL | non-polymer | 380.4 | 1 | Chemie (ZK5) | |||
| 3 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | water | water | 18.0 | 106 | Chemie (HOH) |
Sequence modifications
A: 670 - 917 (UniProt: P10275)
| PDB | External Database | Details |
|---|---|---|
| His 701 | Leu 701 | engineered mutation |
| Ala 877 | Thr 877 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28939.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 475.4 | |
| All* | Total formula weight | 29415.4 |
