1FK8

THE CRYSTAL STRUCTURE OF THE BINARY COMPLEX WITH NAD OF 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE FROM COMAMONAS TESTOSTERONI, A MEMBER OF THE SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY

Summary for 1FK8

Related1FJH
Descriptor3ALPHA-HYDROXYSTEROID DEHYDROGENASE/CARBONYL REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
Functional Keywordsshort chain dehydrogenase, sdr, carbonyl reductase, steroid, hydroxysteroid, xenobiotic, metyrapone, oligomerisation, comamonas testosteroni, nad, nicotinamide adenine dinucleotide, substrate binding loop, oxidoreductase
Biological sourceComamonas testosteroni
Total number of polymer chains2
Total molecular weight54167.71
Authors
Grimm, C.,Ficner, R.,Maser, E.,Klebe, G.,Reuter, K. (deposition date: 2000-08-09, release date: 2001-01-17, Last modification date: 2017-10-04)
Primary citation
Grimm, C.,Maser, E.,Mobus, E.,Klebe, G.,Reuter, K.,Ficner, R.
The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase family.
J.Biol.Chem., 275:41333-41339, 2000
PubMed: 11007791 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M007559200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.95 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers150.2%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report