1FCU

CRYSTAL STRUCTURE (TRIGONAL) OF BEE VENOM HYALURONIDASE

Summary for 1FCU

• Entry DOI: 10.2210/pdb1fcu/pdb
• Related: 1FCQ 1FCV
• Descriptor: HYALURONOGLUCOSAMINIDASE (2 entities in total)
• Functional Keywords: 7 stranded (beta/alpha) tim barrel, allergen, glycosidase family 56, hydrolase
• Biological source: Apis mellifera (honey bee)
• Cellular location: Secreted: Q08169
• Total number of polymer chains: 1
• Total formula weight: 40901.33

Authors

Markovic-Housley, Z.,Miglierini, G.,Soldatova, L.,Rizkallah, P.J.,Mueller, U.,Schirmer, T. (deposition date: 2000-07-19, release date: 2001-10-01, Last modification date: 2024-10-09)

Primary citation

Markovic-Housley, Z.,Miglierini, G.,Soldatova, L.,Rizkallah, P.J.,Muller, U.,Schirmer, T.
Crystal structure of hyaluronidase, a major allergen of bee venom.
Structure Fold.Des., 8:1025-1035, 2000

PubMed Abstract: Hyaluronic acid (HA) is the most abundant glycosaminoglycan of vertebrate extracellular spaces and is specifically degraded by a beta-1,4 glycosidase. Bee venom hyaluronidase (Hya) shares 30% sequence identity with human hyaluronidases, which are involved in fertilization and the turnover of HA. On the basis of sequence similarity, mammalian enzymes and Hya are assigned to glycosidase family 56 for which no structure has been reported yet.

PubMed: 11080624
DOI: 10.1016/S0969-2126(00)00511-6

Experimental method

X-RAY DIFFRACTION (2.1 Å)