1FCU

CRYSTAL STRUCTURE (TRIGONAL) OF BEE VENOM HYALURONIDASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004415	molecular_function	hyalurononglucosaminidase activity
A	0005576	cellular_component	extracellular region
A	0005975	biological_process	carbohydrate metabolic process
A	0006952	biological_process	defense response
A	0008152	biological_process	metabolic process
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0030214	biological_process	hyaluronan catabolic process
A	0031410	cellular_component	cytoplasmic vesicle

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:11080624

Chain	Residue	Details
A	GLU113

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN83

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:10998264

Chain	Residue	Details
A	ASN231

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 616

Chain	Residue	Details
A	ASP111	electrostatic stabiliser, modifies pKa, steric role
A	GLU113	activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor
A	TYR184	steric role
A	TYR227	electrostatic stabiliser, steric role, transition state stabiliser
A	TRP301	steric role

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