1F93

CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE DIMERIZATION DOMAIN OF HNF-1 ALPHA AND THE COACTIVATOR DCOH

1F93 の概要

• エントリーDOI: 10.2210/pdb1f93/pdb
• 分子名称: DIMERIZATION COFACTOR OF HEPATOCYTE NUCLEAR FACTOR 1-ALPHA, HEPATOCYTE NUCLEAR FACTOR 1-ALPHA (3 entities in total)
• 機能のキーワード: four-helix bundle, transcriptional activator-coactivator complex, dimerization domain, transcription
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• 細胞内の位置: Cytoplasm: P61459; Nucleus: P22361
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 62180.96

構造登録者

Rose, R.B.,Bayle, J.H.,Endrizzi, J.A.,Cronk, J.D.,Crabtree, G.R.,Alber, T. (登録日: 2000-07-06, 公開日: 2000-09-20, 最終更新日: 2011-07-13)

• 主引用文献: Rose, R.B.,Bayle, J.H.,Endrizzi, J.A.,Cronk, J.D.,Crabtree, G.R.,Alber, T.; Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha.; Nat.Struct.Biol., 7:744-748, 2000; PubMed: 10966642; DOI: 10.1038/78966

実験手法

X-RAY DIFFRACTION (2.6 Å)