1EER
CRYSTAL STRUCTURE OF HUMAN ERYTHROPOIETIN COMPLEXED TO ITS RECEPTOR AT 1.9 ANGSTROMS
Summary for 1EER
Entry DOI | 10.2210/pdb1eer/pdb |
Descriptor | ERYTHROPOIETIN, ERYTHROPOIETIN RECEPTOR (3 entities in total) |
Functional Keywords | erythropoietin, erythropoietin receptor, signal transduction, hematopoietic cytokine, cytokine receptor class 1, complex (cytokine-receptor), complex (cytokine-receptor) complex, complex (cytokine/receptor) |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01588 Cell membrane; Single-pass type I membrane protein. Isoform EPOR-S: Secreted: P19235 |
Total number of polymer chains | 3 |
Total formula weight | 68844.19 |
Authors | Syed, R.S.,Li, C. (deposition date: 1998-07-24, release date: 1999-10-01, Last modification date: 2021-11-03) |
Primary citation | Syed, R.S.,Reid, S.W.,Li, C.,Cheetham, J.C.,Aoki, K.H.,Liu, B.,Zhan, H.,Osslund, T.D.,Chirino, A.J.,Zhang, J.,Finer-Moore, J.,Elliott, S.,Sitney, K.,Katz, B.A.,Matthews, D.J.,Wendoloski, J.J.,Egrie, J.,Stroud, R.M. Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature, 395:511-516, 1998 Cited by PubMed: 9774108DOI: 10.1038/26773 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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