1E82

Endothiapepsin complex with renin inhibitor MERCK-KGAA-EMD59601

Summary for 1E82

Related4APE 1E5O 1E80 1E81 1EED 1ENT 2ER0 4ER1 5ER1 4ER2 5ER2 3ER3 4ER4 3ER5 2ER6 2ER7 1ER8 2ER9 1EPL 1EPM 1EPN 1EPO 1EPP 1EPQ 1EPR
DescriptorENDOTHIAPEPSIN, (2S)-1-{[(2R)-1-{[(2S,3R)-1-cyclohexyl-3-hydroxy-4-(pyridin-4-yloxy)butan-2-yl]amino}-3-(methylsulfanyl)-1-oxopropan-2-yl]amino}-1-oxo-3-phenylpropan-2-yl 4-aminopiperidine-1-carboxylate (3 entities in total)
Functional Keywordsacid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceENDOTHIA PARASITICA
Total number of polymer chains1
Total molecular weight34469.7
Authors
Read, J.A.,Cooper, J.B.,Toldo, L.,Rippmann, F.,Raddatz, P. (deposition date: 2000-09-15, release date: 2000-10-19, Last modification date: 2011-07-13)
Primary citation
Read, J.A.
Refinement of Four Endothiapepsin Inhibitor Complexes. Crystallographic Studies of Cytochrome Ch from Methylobacterium Extorquens and Inhibitor Complexes of Aspartic Proteinases.
Thesis, 1999
Experimental method
X-RAY DIFFRACTION (2.05 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers307.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report