1EPP

ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-130,693 (MAS PHE LYS+MTF STA MBA)

Summary for 1EPP

Entry DOI	10.2210/pdb1epp/pdb
Related	1EPQ
Related PRD ID	PRD_000392
Descriptor	ENDOTHIAPEPSIN, SULFATE ION, N-(dimethylsulfamoyl)-L-phenylalanyl-N-[(1S,2S)-2-hydroxy-4-{[(2S)-2-methylbutyl]amino}-1-(2-methylpropyl)-4-oxobutyl]-N~6~-(methylcarbamothioyl)-L-lysinamide, ... (4 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, acid proteinase, hydrolase/hydrolase inhibitor
Biological source	Cryphonectria parasitica (chestnut blight fungus)
Total number of polymer chains	1
Total formula weight	34705.95
Authors	Wallace, B.A.,Cooper, J.B.,Blundell, T.L. (deposition date: 1994-07-27, release date: 1994-12-20, Last modification date: 2017-11-29)
Primary citation	Lunney, E.A.,Hamilton, H.W.,Hodges, J.C.,Kaltenbronn, J.S.,Repine, J.T.,Badasso, M.,Cooper, J.B.,Dealwis, C.,Wallace, B.A.,Lowther, W.T. Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors. J.Med.Chem., 36:3809-3820, 1993 Cited by PubMed: 8254610 DOI: 10.1021/jm00076a008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation