1E80

Endothiapepsin complex with renin inhibitor MERCK-KGAA-EMD56133

Summary for 1E80

• Entry DOI: 10.2210/pdb1e80/pdb
• Related: 1E5O 1E81 1E82 1EED 1ENT 1EPL 1EPM 1EPN 1EPO 1EPP 1EPQ 1EPR 1ER8 2ER0 2ER6 2ER7 2ER9 3ER3 3ER5 4APE 4ER1 4ER2 4ER4 5ER1 5ER2
• Related PRD ID: PRD_000296
• Descriptor: ENDOTHIAPEPSIN, 4-amino-N-{(1R,8R,9R,13R)-16-(4-amino-2-methylpyrimidin-5-yl)-1-benzyl-8-(cyclohexylmethyl)-9-hydroxy-13-[(1S)-1-methylpropyl]-2,6,11,14-tetraoxo-3,7,12,15-tetraazahexadec-1-yl}piperidine-1-carboxamide (3 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, acid proteinase, hydrolase/hydrolase inhibitor
• Biological source: ENDOTHIA PARASITICA
• Total number of polymer chains: 1
• Total formula weight: 34606.87

Authors

Read, J.A.,Cooper, J.B.,Toldo, L.,Rippmann, F.,Raddatz, P. (deposition date: 2000-09-15, release date: 2000-09-26, Last modification date: 2023-12-13)

• Primary citation: Read, J.A.; Refinement of Four Endothiapepsin Inhibitor Complexes. Crystallographic Studies of Cytochrome Ch from Methylobacterium Extorquens and Inhibitor Complexes of Aspartic Proteinases.; Ph D Thesis, 1999

Experimental method

X-RAY DIFFRACTION (2.05 Å)