1E0O

CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX

1E0O の概要

• エントリーDOI: 10.2210/pdb1e0o/pdb
• 関連するPDBエントリー: 1AXM 1CVS 1DJS 2AXM
• 分子名称: FIBROBLAST GROWTH FACTOR 1, FIBROBLAST GROWTH FACTOR RECEPTOR 2, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: growth factor, receptor tyrosine kinase, heparin, ternary complex, signal transduction
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 84448.54

構造登録者

Pellegrini, L.,Burke, D.F.,von Delft, F.,Mulloy, B.,Blundell, T.L. (登録日: 2000-04-03, 公開日: 2000-10-23, 最終更新日: 2020-07-29)

• 主引用文献: Pellegrini, L.,Burke, D.F.,von Delft, F.,Mulloy, B.,Blundell, T.L.; Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Ligand and Heparin; Nature, 407:1029-, 2000; PubMed: 11069186; DOI: 10.1038/35039551

実験手法

X-RAY DIFFRACTION (2.8 Å)