1D6M

CRYSTAL STRUCTURE OF E. COLI DNA TOPOISOMERASE III

Summary for 1D6M

Entry DOI	10.2210/pdb1d6m/pdb
Descriptor	DNA TOPOISOMERASE III (1 entity in total)
Functional Keywords	dna topoisomerase, decatenating enzyme, isomerase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	73322.78
Authors	Mondragon, A.,DiGate, R. (deposition date: 1999-10-14, release date: 2000-10-14, Last modification date: 2024-02-07)
Primary citation	Mondragon, A.,DiGate, R. The structure of Escherichia coli DNA topoisomerase III. Structure Fold.Des., 7:1373-1383, 1999 Cited by PubMed Abstract: DNA topoisomerases are enzymes that change the topology of DNA. Type IA topoisomerases transiently cleave one DNA strand in order to pass another strand or strands through the break. In this manner, they can relax negatively supercoiled DNA and catenate and decatenate DNA molecules. Structural information on Escherichia coli DNA topoisomerase III is important for understanding the mechanism of this type of enzyme and for studying the mechanistic differences among different members of the same subfamily. PubMed: 10574789 DOI: 10.1016/S0969-2126(00)80027-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation