1C8M

REFINED CRYSTAL STRUCTURE OF HUMAN RHINOVIRUS 16 COMPLEXED WITH VP63843 (PLECONARIL), AN ANTI-PICORNAVIRAL DRUG CURRENTLY IN CLINICAL TRIALS

Summary for 1C8M

• Entry DOI: 10.2210/pdb1c8m/pdb
• Related: 1AYM 1AYN 1QJU 1QJX 1QJY
• Descriptor: HUMAN RHINOVIRUS 16 COAT PROTEIN, ZINC ION, 3-{3,5-DIMETHYL-4-[3-(3-METHYL-ISOXAZOL-5-YL)-PROPOXY]-PHENYL}-5-TRIFLUOROMETHYL-[1,2,4]OXADIAZOLE, ... (7 entities in total)
• Functional Keywords: rhinovirus coat protein, human rhinovirus 16, antiviral compound, drug, win compound, icosahedral virus, virus
• Biological source: Human rhinovirus 16; More
• Cellular location: Capsid protein VP0: Virion . Capsid protein VP4: Virion . Capsid protein VP2: Virion . Capsid protein VP3: Virion . Capsid protein VP1: Virion . Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3AB: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Viral protein genome-linked: Virion . Protease 3C: Host cytoplasm . Protein 3CD: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : Q82122 Q82122 Q82122 Q82122
• Total number of polymer chains: 4
• Total formula weight: 95626.94

Authors

Chakravarty, S.,Bator, C.M.,Pevear, D.C.,Diana, G.D.,Rossmann, M.G. (deposition date: 2000-05-26, release date: 2000-11-22, Last modification date: 2023-09-20)

• Primary citation: CHAKRAVARTY, S.,BATOR, C.M.,PEVEAR, D.C.,DIANA, G.D.,ROSSMANN, M.G.; THE REFINED STRUCTURE OF A PICORNAVIRUS INHIBITOR CURRENTLY IN CLINICAL TRIALS, WHEN COMPLEXED WITH HUMAN RHINOVIRUS 16; to be published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)