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1C8M

REFINED CRYSTAL STRUCTURE OF HUMAN RHINOVIRUS 16 COMPLEXED WITH VP63843 (PLECONARIL), AN ANTI-PICORNAVIRAL DRUG CURRENTLY IN CLINICAL TRIALS

Functional Information from GO Data
ChainGOidnamespacecontents
10005198molecular_functionstructural molecule activity
20005198molecular_functionstructural molecule activity
30005198molecular_functionstructural molecule activity
40005198molecular_functionstructural molecule activity
40019028cellular_componentviral capsid
Functional Information from PDB Data
site_idAC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE ZN 1 6000
ChainResidue
1HIS134

site_idAC2
Number of Residues17
DetailsBINDING SITE FOR RESIDUE W11 1 7001
ChainResidue
1ILE77
1ILE98
1LEU100
1MET124
1TYR142
1MET143
1TYR144
1ALA166
1VAL168
1PHE179
1LEU181
1LEU184
1TYR190
1ASN212
1MET214
1LEU217
1HOH5378

site_idION
Number of Residues3
DetailsPUTATIVE ZINC BINDING SITE ON ICOSAHEDRAL FIVE-FOLD AXIS. ION LIGANDED BY FIVE SYMMETRY RELATED HISTIDINES (HIS 1 134). EXTERIOR OF SITE SURROUNDED BY A WIDER CIRCLE OF FIVE HISTIDINES (HIS 2 228)
ChainResidue
1HIS134
1HIS228
1ZN6000

site_idPOC
Number of Residues4
DetailsAN ANTIVIRAL COMPOUND IS FOUND IN A POCKET OF VP1
ChainResidue
1PHE179
1MET214
1LEU217
1W117001

site_idRNA
Number of Residues2
DetailsRNA OBSERVED INTERACTING WITH THESE RESIDUES ON THE INTERIOR SURFACE OF VIRAL PROTEIN CAPSID. NON-CONSERVATIVE MUTATION OF TRP 2 38 GIVES NON-VIABLE VIRUS.
ChainResidue
2TRP38
3PHE35

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P03300
ChainResidueDetails
4SER69

site_idSWS_FT_FI2
Number of Residues1
DetailsLIPID: N-myristoyl glycine; by host => ECO:0000250|UniProtKB:P03300
ChainResidueDetails
4ALA2

219140

PDB entries from 2024-05-01

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