1C2P

HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE

Summary for 1C2P

• Entry DOI: 10.2210/pdb1c2p/pdb
• Descriptor: RNA-DEPENDENT RNA POLYMERASE (2 entities in total)
• Functional Keywords: polymerase rna-dependent rna polymerase hepatitis c virus ns5b apoenzyme, transferase
• Biological source: Hepatitis C virus
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26663
• Total number of polymer chains: 2
• Total formula weight: 129058.34

Authors

Lesburg, C.A.,Cable, M.B.,Ferrari, E.,Hong, Z.,Mannarino, A.F.,Weber, P.C. (deposition date: 1999-07-26, release date: 2000-04-05, Last modification date: 2018-01-31)

• Primary citation: Lesburg, C.A.,Cable, M.B.,Ferrari, E.,Hong, Z.,Mannarino, A.F.,Weber, P.C.; Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site.; Nat.Struct.Biol., 6:937-943, 1999; PubMed: 10504728; DOI: 10.1038/13305

Experimental method

X-RAY DIFFRACTION (1.9 Å)