1BXS

SHEEP LIVER CLASS 1 ALDEHYDE DEHYDROGENASE WITH NAD BOUND

Summary for 1BXS

Entry DOI	10.2210/pdb1bxs/pdb
Descriptor	ALDEHYDE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
Functional Keywords	aldehyde dehydrogenase, retinal, class 1, tetramer, nad, cytosolic, oxidoreductase
Biological source	Ovis aries (sheep)
Cellular location	Cytoplasm: P51977
Total number of polymer chains	4
Total formula weight	222196.06
Authors	Moore, S.A.,Baker, H.M.,Blythe, T.J.,Kitson, K.E.,Kitson, T.M.,Baker, E.N. (deposition date: 1998-10-08, release date: 1999-04-27, Last modification date: 2024-05-22)
Primary citation	Moore, S.A.,Baker, H.M.,Blythe, T.J.,Kitson, K.E.,Kitson, T.M.,Baker, E.N. Sheep liver cytosolic aldehyde dehydrogenase: the structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases. Structure, 6:1541-1551, 1998 Cited by PubMed Abstract: . Enzymes of the aldehyde dehydrogenase family are required for the clearance of potentially toxic aldehydes, and are essential for the production of key metabolic regulators. The cytosolic, or class 1, aldehyde dehydrogenase (ALDH1) of higher vertebrates has an enhanced specificity for all-trans retinal, oxidising it to the powerful differentiation factor all-trans retinoic acid. Thus, ALDH1 is very likely to have a key role in vertebrate development. PubMed: 9862807 DOI: 10.1016/S0969-2126(98)00152-X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation