1BXS
SHEEP LIVER CLASS 1 ALDEHYDE DEHYDROGENASE WITH NAD BOUND
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001523 | biological_process | retinoid metabolic process |
| A | 0001758 | molecular_function | retinal dehydrogenase activity |
| A | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0009449 | biological_process | gamma-aminobutyric acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0018479 | molecular_function | benzaldehyde dehydrogenase (NAD+) activity |
| A | 0019145 | molecular_function | aminobutyraldehyde dehydrogenase (NAD+) activity |
| A | 0030392 | biological_process | fructosamine catabolic process |
| A | 0030424 | cellular_component | axon |
| A | 0036438 | biological_process | maintenance of lens transparency |
| A | 0042572 | biological_process | retinol metabolic process |
| A | 0042995 | cellular_component | cell projection |
| A | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| A | 0045202 | cellular_component | synapse |
| A | 0051287 | molecular_function | NAD binding |
| A | 0106373 | molecular_function | 3-deoxyglucosone dehydrogenase activity |
| A | 0110095 | biological_process | cellular detoxification of aldehyde |
| B | 0001523 | biological_process | retinoid metabolic process |
| B | 0001758 | molecular_function | retinal dehydrogenase activity |
| B | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0009449 | biological_process | gamma-aminobutyric acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0018479 | molecular_function | benzaldehyde dehydrogenase (NAD+) activity |
| B | 0019145 | molecular_function | aminobutyraldehyde dehydrogenase (NAD+) activity |
| B | 0030392 | biological_process | fructosamine catabolic process |
| B | 0030424 | cellular_component | axon |
| B | 0036438 | biological_process | maintenance of lens transparency |
| B | 0042572 | biological_process | retinol metabolic process |
| B | 0042995 | cellular_component | cell projection |
| B | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| B | 0045202 | cellular_component | synapse |
| B | 0051287 | molecular_function | NAD binding |
| B | 0106373 | molecular_function | 3-deoxyglucosone dehydrogenase activity |
| B | 0110095 | biological_process | cellular detoxification of aldehyde |
| C | 0001523 | biological_process | retinoid metabolic process |
| C | 0001758 | molecular_function | retinal dehydrogenase activity |
| C | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0009449 | biological_process | gamma-aminobutyric acid biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0018479 | molecular_function | benzaldehyde dehydrogenase (NAD+) activity |
| C | 0019145 | molecular_function | aminobutyraldehyde dehydrogenase (NAD+) activity |
| C | 0030392 | biological_process | fructosamine catabolic process |
| C | 0030424 | cellular_component | axon |
| C | 0036438 | biological_process | maintenance of lens transparency |
| C | 0042572 | biological_process | retinol metabolic process |
| C | 0042995 | cellular_component | cell projection |
| C | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| C | 0045202 | cellular_component | synapse |
| C | 0051287 | molecular_function | NAD binding |
| C | 0106373 | molecular_function | 3-deoxyglucosone dehydrogenase activity |
| C | 0110095 | biological_process | cellular detoxification of aldehyde |
| D | 0001523 | biological_process | retinoid metabolic process |
| D | 0001758 | molecular_function | retinal dehydrogenase activity |
| D | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006629 | biological_process | lipid metabolic process |
| D | 0009449 | biological_process | gamma-aminobutyric acid biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0018479 | molecular_function | benzaldehyde dehydrogenase (NAD+) activity |
| D | 0019145 | molecular_function | aminobutyraldehyde dehydrogenase (NAD+) activity |
| D | 0030392 | biological_process | fructosamine catabolic process |
| D | 0030424 | cellular_component | axon |
| D | 0036438 | biological_process | maintenance of lens transparency |
| D | 0042572 | biological_process | retinol metabolic process |
| D | 0042995 | cellular_component | cell projection |
| D | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| D | 0045202 | cellular_component | synapse |
| D | 0051287 | molecular_function | NAD binding |
| D | 0106373 | molecular_function | 3-deoxyglucosone dehydrogenase activity |
| D | 0110095 | biological_process | cellular detoxification of aldehyde |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NAD A 550 |
| Chain | Residue |
| A | ILE165 |
| A | PRO226 |
| A | GLY229 |
| A | ALA230 |
| A | PHE243 |
| A | GLY245 |
| A | SER246 |
| A | VAL249 |
| A | ILE253 |
| A | LEU269 |
| A | GLY270 |
| A | ILE166 |
| A | CYS302 |
| A | GLN349 |
| A | LYS352 |
| A | GLU399 |
| A | PHE401 |
| A | PRO167 |
| A | TRP168 |
| A | ASN169 |
| A | LYS192 |
| A | ALA194 |
| A | GLU195 |
| A | GLY225 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NAD B 550 |
| Chain | Residue |
| B | ILE165 |
| B | ILE166 |
| B | PRO167 |
| B | TRP168 |
| B | ASN169 |
| B | LYS192 |
| B | ALA194 |
| B | GLU195 |
| B | GLY225 |
| B | PRO226 |
| B | GLY229 |
| B | ALA230 |
| B | PHE243 |
| B | GLY245 |
| B | SER246 |
| B | VAL249 |
| B | ILE253 |
| B | LEU269 |
| B | GLY270 |
| B | CYS302 |
| B | GLN349 |
| B | LYS352 |
| B | GLU399 |
| B | PHE401 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NAD C 550 |
| Chain | Residue |
| C | ILE165 |
| C | ILE166 |
| C | PRO167 |
| C | TRP168 |
| C | ASN169 |
| C | LYS192 |
| C | ALA194 |
| C | GLU195 |
| C | GLY225 |
| C | GLY229 |
| C | ALA230 |
| C | PHE243 |
| C | GLY245 |
| C | SER246 |
| C | VAL249 |
| C | ILE253 |
| C | LEU269 |
| C | GLY270 |
| C | CYS302 |
| C | GLN349 |
| C | LYS352 |
| C | GLU399 |
| C | PHE401 |
| site_id | AC4 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NAD D 550 |
| Chain | Residue |
| D | ILE165 |
| D | ILE166 |
| D | PRO167 |
| D | TRP168 |
| D | ASN169 |
| D | LYS192 |
| D | ALA194 |
| D | GLU195 |
| D | GLY225 |
| D | PRO226 |
| D | GLY229 |
| D | ALA230 |
| D | PHE243 |
| D | GLY245 |
| D | SER246 |
| D | VAL249 |
| D | ILE253 |
| D | LEU269 |
| D | GLY270 |
| D | CYS302 |
| D | GLN349 |
| D | LYS352 |
| D | GLU399 |
| D | PHE401 |
Functional Information from PROSITE/UniProt
| site_id | PS00070 |
| Number of Residues | 12 |
| Details | ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FyHQGQCCIAAS |
| Chain | Residue | Details |
| A | PHE295-SER306 |
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP |
| Chain | Residue | Details |
| A | LEU267-PRO274 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10007, ECO:0000255|PROSITE-ProRule:PRU10008 |
| Chain | Residue | Details |
| A | LEU269 | |
| B | LEU269 | |
| C | LEU269 | |
| D | LEU269 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile => ECO:0000303|PubMed:9862807 |
| Chain | Residue | Details |
| A | ILE303 | |
| B | ILE303 | |
| C | ILE303 | |
| D | ILE303 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26373694, ECO:0000269|PubMed:9862807, ECO:0007744|PDB:1BXS, ECO:0007744|PDB:5AC0 |
| Chain | Residue | Details |
| A | PRO167 | |
| B | SER246 | |
| B | GLN349 | |
| B | ILE400 | |
| C | PRO167 | |
| C | PRO193 | |
| C | PRO226 | |
| C | SER246 | |
| C | GLN349 | |
| C | ILE400 | |
| D | PRO167 | |
| A | PRO193 | |
| D | PRO193 | |
| D | PRO226 | |
| D | SER246 | |
| D | GLN349 | |
| D | ILE400 | |
| A | PRO226 | |
| A | SER246 | |
| A | GLN349 | |
| A | ILE400 | |
| B | PRO167 | |
| B | PRO193 | |
| B | PRO226 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26373694, ECO:0007744|PDB:5AC0 |
| Chain | Residue | Details |
| A | LEU269 | |
| B | LEU269 | |
| C | LEU269 | |
| D | LEU269 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P20000 |
| Chain | Residue | Details |
| A | PHE170 | |
| B | PHE170 | |
| C | PHE170 | |
| D | PHE170 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylserine => ECO:0000250|UniProtKB:P15437 |
| Chain | Residue | Details |
| A | SER2 | |
| B | SER2 | |
| C | SER2 | |
| D | SER2 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 32 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P00352 |
| Chain | Residue | Details |
| A | LEU91 | |
| B | THR128 | |
| B | LEU252 | |
| B | ILE353 | |
| B | LEU367 | |
| B | PHE410 | |
| B | ARG419 | |
| B | ILE495 | |
| C | LEU91 | |
| C | THR128 | |
| C | LEU252 | |
| A | THR128 | |
| C | ILE353 | |
| C | LEU367 | |
| C | PHE410 | |
| C | ARG419 | |
| C | ILE495 | |
| D | LEU91 | |
| D | THR128 | |
| D | LEU252 | |
| D | ILE353 | |
| D | LEU367 | |
| A | LEU252 | |
| D | PHE410 | |
| D | ARG419 | |
| D | ILE495 | |
| A | ILE353 | |
| A | LEU367 | |
| A | PHE410 | |
| A | ARG419 | |
| A | ILE495 | |
| B | LEU91 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P00352 |
| Chain | Residue | Details |
| A | PRO337 | |
| B | PRO337 | |
| C | PRO337 | |
| D | PRO337 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00352 |
| Chain | Residue | Details |
| A | LEU413 | |
| B | LEU413 | |
| C | LEU413 | |
| D | LEU413 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| A | CYS302 | |
| A | GLU268 | |
| A | ASN169 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| B | CYS302 | |
| B | GLU268 | |
| B | ASN169 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| C | CYS302 | |
| C | GLU268 | |
| C | ASN169 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| D | CYS302 | |
| D | GLU268 | |
| D | ASN169 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| A | CYS302 | |
| A | LYS192 | |
| A | GLU268 | |
| A | GLU399 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| B | CYS302 | |
| B | LYS192 | |
| B | GLU268 | |
| B | GLU399 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| C | CYS302 | |
| C | LYS192 | |
| C | GLU268 | |
| C | GLU399 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| D | CYS302 | |
| D | LYS192 | |
| D | GLU268 | |
| D | GLU399 |
