1YC5

Sir2-p53 peptide-nicotinamide

Summary for 1YC5

• Entry DOI: 10.2210/pdb1yc5/pdb
• Related: 1YC2
• Descriptor: NAD-dependent deacetylase, Cellular tumor antigen p53 peptide, ZINC ION, ... (5 entities in total)
• Functional Keywords: sir2, sirtuin, sir2tm, sirt1, p53, nicotinamide, hydrolase
• Biological source: Thermotoga maritima; More
• Cellular location: Cytoplasm (Probable): Q9WYW0; Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: Q9NP68
• Total number of polymer chains: 2
• Total formula weight: 29896.85

Authors

Avalos, J.L.,Bever, M.K.,Wolberger, C. (deposition date: 2004-12-21, release date: 2005-04-26, Last modification date: 2011-07-13)

• Primary citation: Avalos, J.L.,Bever, K.M.,Wolberger, C.; Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme.; Mol.Cell, 17:855-868, 2005; PubMed: 15780941; DOI: 10.1016/j.molcel.2005.02.022

Experimental method

X-RAY DIFFRACTION (1.4 Å)