1X7A
Porcine Factor IXa Complexed to 1-{3-[amino(imino)methyl]phenyl}-N-[4-(1H-benzimidazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
Summary for 1X7A
Entry DOI | 10.2210/pdb1x7a/pdb |
Related | 1PFX |
Descriptor | Coagulation Factor IXa, Coagulation Factor IX, light chain, 1-{3-[AMINO(IMINO)METHYL]PHENYL}-N-[4-(1H-BENZIMIDAZOL-1-YL)-2-FLUOROPHENYL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXAMIDE (3 entities in total) |
Functional Keywords | inhibition; x-ray structure, blood clotting, hydrolase |
Biological source | Sus scrofa (pig) More |
Cellular location | Secreted: P16293 P16293 |
Total number of polymer chains | 2 |
Total formula weight | 43018.47 |
Authors | Alexander, R.S.,Smallwood, A.M.,Smallheer, J.M.,Wang, J.,Wang, S.,Nakajima, S.,Rossi, K.A.,Barbera, F.,Burdick, D.,Luettgen, J.M. (deposition date: 2004-08-13, release date: 2005-08-16, Last modification date: 2011-07-13) |
Primary citation | Smallheer, J.M.,Alexander, R.S.,Wang, J.,Wang, S.,Nakajima, S.,Rossi, K.A.,Smallwood, A.,Barbera, F.,Burdick, D.,Luettgen, J.M.,Knabb, R.M.,Wexler, R.R.,Jadhav, P.K. SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa Bioorg.Med.Chem.Lett., 14:5263-5267, 2004 Cited by PubMed: 15454208DOI: 10.1016/j.bmcl.2004.08.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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